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Testosterone Therapy With Subcutaneous Injections: A Safe, Practical, and Reasonable Option

Testosterone Patch vs Injection: Comprehensive Comparison for Mens Health

Testosterone injections deliver the hormone directly into the muscle, providing a more immediate and sometimes higher dose of testosterone. This method is often used by men who require more significant hormone replacement or those who prefer less frequent dosing schedules. Injections are typically administered every 1-4 weeks, depending on the type of testosterone and the individual’s medical needs. Four participants reported small, painless nodules that resolved within 2 days, while 2 participants developed urticaria at the injection site within a few hours that persisted for up to 3 days.

Also, the steroids are often combined (“stacked”) with other substances like stimulants, pain relievers, and growth hormones to boost the overall muscle-building effect. Testosterone replacement therapy can have side effects, and the long-term risks aren’t known. Only men with symptoms of low testosterone and blood levels that confirm this as the cause of symptoms should consider testosterone replacement. Talking with your doctor is the only way to know if testosterone therapy is right for you. It is best to be aware of the possible complications of testosterone injections. Doctors should do a thorough evaluation and, if testosterone replacement therapy is an option, discuss the benefits and risks with the person before prescribing it.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving testosterone injection. The dosage can vary, but commonly, one tablet of 25 mg per day is what will be prescribed. As always, adhere strictly to your prescribing doctor’s instructions, your dosage will have been calibrated based on your hormonal levels and response to treatment.

And all the other benefits that come with raising your testosterone safely. You can connect multiple needles to a syringe, depending on the action required. Needle diameter is measured by gauge numbers, which indicates the bore of a needle’s lumen (a fancy word for the hole at the tip of the needle). The higher the gauge number, the smaller or thinner the hole; the lower the gauge number, the bigger or thicker the hole. Higher gauge needles can reduce pain when injecting, but larger needles are required for injecting larger volumes of oil-based substances (like testosterone) into the muscle. Reusing needles is problematic because they are unsanitary but also because after the first use, the needle is blunted immediately, meaning the next time you use it will be more painful. Always keep a fresh supply of new needles in your home and use one for each injection.

Other symptoms of male hypogonadism may include fatigue, irritability, depressed mood, insomnia, impaired cognitive functions, mood swings and lack of motivation. Physical indicators of low testosterone may include increased body fat, difficulty building muscle mass, impaired recovery from work-outs and reduced exercise endurance. The most recent FDA-approved oral TRT medications include Tlando®, Jatenzo®, and Kyzatrex®, which all bypass the liver and are absorbed by the lymphatic system. All three medications have been shown to restore testosterone levels in hypogonadal men to within the normal range. Meanwhile, clinical trial results showed that 88% of patients treated with Kyzatrex achieved an average plasma total testosterone concentration within the normal range clitoris on t the final day of the study. Some men may experience immediate side effects from testosterone treatment. These can include acne, disturbed breathing while sleeping, breast swelling or tenderness, or swelling in the ankles.

Men who present with severe depressive symptoms or a history of depression should be referred to psychiatry. While testosterone therapy may help depressive symptoms, pharmacologic treatment or cognitive therapy may also be warranted in these men. Men with depressive symptoms that fail to respond to adequate testosterone replacement should also be referred for psychiatric consultation. Testosterone passes through the blood brain barrier in support of normal brain function. Testosterone receptors are located in several parts of the brain including the cortex and hippocampus. There is no doubt that testosterone along with some of its metabolites play a role in normal mental health. Men with a history of venous thromboembolism must also be approached cautiously and consultation with hematology is strongly recommended.

The patient’s medical record must contain documentation that fully supports the medical necessity for services included within the related LCD (see Coverage Indications, Limitations and/or Medical Necessity). This documentation includes, but is not limited to, relevant medical history, physical examination, and results of pertinent diagnostic tests or procedures. Procedure codes may be subject to NCCI edits or Outpatient Prospective Payment System (OPPS) packaging edits. For services requiring a referring/ordering physician, the name and National Provider Identifier (NPI) of the referring/ordering physician must be reported on the claim.

While these injections can lead to improved energy, mental acuity, and sexual function, they also come with some safety concerns. Both testosterone patches and injections offer effective ways to treat low testosterone levels, but the best choice will depend on individual needs and lifestyle factors. Patches provide a steady release of testosterone and are non-invasive, making them convenient for those who prefer not to deal with needles. In contrast, injections offer higher doses and less frequent administration but come with potential discomfort and hormone fluctuations.

Without adequate testosterone, a man may lose their sex drive, experience erectile dysfunction, feel depressed, have a decreased sense of well-being, fatigue, and have difficulty concentrating. Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration. Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids.